| Ahab is an algorithm which was designed to detect enhancers and binding sites for transcription factors in the genomes of multicellular organisms [1]. Several Ahab predictions have been successfully tested experimentally [2]. This webserver [3] allows remote users to run Ahab and to locate putative enhancers and binding sites in DNA sequences. |
| Two different Ahab webservers can be used: the default version (suitable to analyze any DNA sequences), and the fly version, which allows users to analyze specific loci in the Drosophila melanogaster genome together with the homologous regions in Drosophila pseudoobscura by simply specifying keywords (gene names, symbols, etc) and to view the output graphically embedded in the fly genomic annotation via the Generic Genome Browser. We have mapped dozens of enhancer elements and hundreds of binding sites which previously have been mined from the literature by D. Papatsenko (NYU) [4] to the fly genome and display this information together with the BDGP fly annotation release 3.1. |
| The Ahab webserver is work in progress. However, please email general suggestions or critique to Nikolaus Rajewsky. If you publish Ahab webserver results, please cite [3]. The Ahab webserver is part of an effort by the Rajewsky lab at NYU to develop algorithms and tools for the detection, characterization, and annotation of regulatory elements in the genomes of multicellular organisms. |
| If you cannot access the links, make sure your javascript is enabled. |
| Follow this link to go directly to our Fly Generic Genome Browser where you can browse the fly genome annotation BDGP release 3.1 together with known regulatory elements, microRNA genes, and other regulatory data (or upload your own annotation). |